Tankyrase 1 regulates centrosome function by controlling CPAP stability

CPAP—a gene mutated in primary microcephaly—is required for procentriole formation. Here we show that CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1. CPAP is PARsylated by tankyrase 1 in vitro and in vivo. Overexpression of tankyrase 1 leads to CPAP protea...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Mi Kyung, Dudognon, Charles, Smith, Susan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Scientific Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410387/
https://ncbi.nlm.nih.gov/pubmed/22699936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.86
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