Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically regulated, pharmacologically targetable, risk pathway associated with schizophrenia and with ErbB4 genetic variation involving i...

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Detalhes bibliográficos
Main Authors: Law, Amanda J., Wang, Yanhong, Sei, Yoshitatsu, O’Donnell, Patricio, Piantadosi, Patrick, Papaleo, Francesco, Straub, Richard E., Huang, Wenwei, Thomas, Craig J., Vakkalanka, Radhakrishna, Besterman, Aaron D., Lipska, Barbara K., Hyde, Thomas M., Harrison, Paul J., Kleinman, Joel E., Weinberger, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409795/
https://ncbi.nlm.nih.gov/pubmed/22689948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206118109
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