Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically regulated, pharmacologically targetable, risk pathway associated with schizophrenia and with ErbB4 genetic variation involving i...

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Autori principali: Law, Amanda J., Wang, Yanhong, Sei, Yoshitatsu, O’Donnell, Patricio, Piantadosi, Patrick, Papaleo, Francesco, Straub, Richard E., Huang, Wenwei, Thomas, Craig J., Vakkalanka, Radhakrishna, Besterman, Aaron D., Lipska, Barbara K., Hyde, Thomas M., Harrison, Paul J., Kleinman, Joel E., Weinberger, Daniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409795/
https://ncbi.nlm.nih.gov/pubmed/22689948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206118109
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