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Structural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
Mutations in the proline/tyrosine–nuclear localization signal (PY-NLS) of the Fused in Sarcoma protein (FUS) cause amyotrophic lateral sclerosis (ALS). Here we report the crystal structure of the FUS PY-NLS bound to its nuclear import receptor Karyopherinβ2 (Kapβ2; also known as Transportin). The FU...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409756/ https://ncbi.nlm.nih.gov/pubmed/22778397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207247109 |
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