Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

Ribonucleases H (RNases H) are endonucleases which cleave the RNA moiety of RNA/DNA hybrids. Their function in mammalian cells is incompletely understood. RNase H2 mutations cause Aicardi-Goutières syndrome, an inflammatory condition clinically overlapping with lupus erythematosus. We show that RNas...

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Detalhes bibliográficos
Main Authors: Hiller, Bjoern, Achleitner, Martin, Glage, Silke, Naumann, Ronald, Behrendt, Rayk, Roers, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409502/
https://ncbi.nlm.nih.gov/pubmed/22802351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120876
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