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Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
Ribonucleases H (RNases H) are endonucleases which cleave the RNA moiety of RNA/DNA hybrids. Their function in mammalian cells is incompletely understood. RNase H2 mutations cause Aicardi-Goutières syndrome, an inflammatory condition clinically overlapping with lupus erythematosus. We show that RNas...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409502/ https://ncbi.nlm.nih.gov/pubmed/22802351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120876 |
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