Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors

Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFβ signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFβ signaling antagonist Lefty also acts through...

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Detaylı Bibliyografya
Asıl Yazarlar: Cheng, Simon K, Olale, Felix, Brivanlou, Ali H, Schier, Alexander F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2004
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC340941/
https://ncbi.nlm.nih.gov/pubmed/14966532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020030
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