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Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease

Currently there is no treatment for juvenile Batten disease, a fatal childhood neurodegenerative disorder caused by mutations in the CLN3 gene. The Cln3-knockout (Cln3(Δex1-6)) mouse model recapitulates several features of the human disorder. Cln3(Δex1-6) mice, similarly to juvenile Batten disease p...

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Dettagli Bibliografici
Autori principali: Kovács, Attila D., Saje, Angelika, Wong, Andrew, Ramji, Serena, Cooper, Jonathan D., Pearce, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408822/
https://ncbi.nlm.nih.gov/pubmed/22683643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.05.040
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