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Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease
Juvenile Batten disease, caused by mutations in the CLN3 gene, is a fatal, incurable neurodegenerative disorder in children. The Cln3-loss-of-function (Cln3(Δex1-6)) mouse model of the disease exhibits many characteristic pathological features of the human disorder including a deficit in motor skill...
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| Veröffentlicht in: | Exp Neurol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418195/ https://ncbi.nlm.nih.gov/pubmed/17963751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.09.012 |
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