AGE-DEPENDENT REDUCTION OF THE PI3K REGULATORY SUBUNIT p85α SUPPRESSES PANCREATIC ACINAR CELL PROLIFERATION

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is important for tissue proliferation. Previously, we found that tissue regeneration after partial pancreatic resection was markedly attenuated in aged mice as compared to young mice and that this attenuation was due to an age-dependent reduction...

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Hauptverfasser: Takahashi, Hitoshi, Okamura, Daiki, Starr, Marlene E., Saito, Hiroshi, Evers, B. Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408710/
https://ncbi.nlm.nih.gov/pubmed/22212451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00787.x
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