AGE-DEPENDENT REDUCTION OF THE PI3K REGULATORY SUBUNIT p85α SUPPRESSES PANCREATIC ACINAR CELL PROLIFERATION

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is important for tissue proliferation. Previously, we found that tissue regeneration after partial pancreatic resection was markedly attenuated in aged mice as compared to young mice and that this attenuation was due to an age-dependent reduction...

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Détails bibliographiques
Auteurs principaux: Takahashi, Hitoshi, Okamura, Daiki, Starr, Marlene E., Saito, Hiroshi, Evers, B. Mark
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408710/
https://ncbi.nlm.nih.gov/pubmed/22212451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00787.x
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