Deletion of p38-alpha MAPK within the Intestinal Epithelium Promotes Colon Tumorigenesis

BACKGROUND: p38-alpha MAPK (p38) is a tumor suppressor often mutated in human cancers, but its specific role in colorectal cancer is not completely understood. Prior studies have found that p38 activity inhibits epithelial proliferation and promotes apoptosis in the intestine. Therefore, we sought t...

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Main Authors: Wakeman, Derek, Schneider, John E., Liu, Jingxia, Wandu, Wambul S., Erwin, Christopher R, Guo, Jun, Stappenbeck, Thaddeus S., Warner, Brad W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408636/
https://ncbi.nlm.nih.gov/pubmed/22828150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2012.05.009
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