Deletion of p38-alpha MAPK within the Intestinal Epithelium Promotes Colon Tumorigenesis

BACKGROUND: p38-alpha MAPK (p38) is a tumor suppressor often mutated in human cancers, but its specific role in colorectal cancer is not completely understood. Prior studies have found that p38 activity inhibits epithelial proliferation and promotes apoptosis in the intestine. Therefore, we sought t...

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Bibliographic Details
Main Authors: Wakeman, Derek, Schneider, John E., Liu, Jingxia, Wandu, Wambul S., Erwin, Christopher R, Guo, Jun, Stappenbeck, Thaddeus S., Warner, Brad W.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408636/
https://ncbi.nlm.nih.gov/pubmed/22828150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2012.05.009
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