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ACTIVATION OF STIM1-ORAI1 INVOLVES AN INTRAMOLECULAR SWITCHING MECHANISM
The stromal interaction molecule, STIM1 regulates Ca(2+) entry via Orai1 channels in response to decreased concentration of ER luminal Ca(2+). In search of a mechanism that switches the cytoplasmic aspect of STIM1 from an inactive to an active state, we identified an acidic motif within the STIM1 co...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408607/ https://ncbi.nlm.nih.gov/pubmed/21081754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001122 |
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