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Molecular anatomy of the early events in STIM1 activation – oligomerization or conformational change?
Decreased luminal endoplasmic reticulum (ER) Ca(2+) concentration triggers oligomerization and clustering of the ER Ca(2+) sensor STIM1 to promote its association with plasma membrane Orai1 Ca(2+) channels leading to increased Ca(2+) influx. A key step in STIM1 activation is the release of its SOAR...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Cell Sci |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Company of Biologists Ltd
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612226/ https://ncbi.nlm.nih.gov/pubmed/28724757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.205583 |
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