Tet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds th...

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Библиографические подробности
Главные авторы: Williams, Kristine, Christensen, Jesper, Pedersen, Marianne Terndrup, Johansen, Jens V., Cloos, Paul A. C., Rappsilber, Juri, Helin, Kristian
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408592/
https://ncbi.nlm.nih.gov/pubmed/21490601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10066
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