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The emerging role of fumarate as an oncometabolite

The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1, that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided significan...

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Bibliografski detalji
Glavni autori: Yang, Ming, Soga, Tomoyoshi, Pollard, Patrick J., Adam, Julie
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Research Foundation 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408580/
https://ncbi.nlm.nih.gov/pubmed/22866264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00085
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