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The emerging role of fumarate as an oncometabolite
The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1, that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided significan...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Research Foundation
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408580/ https://ncbi.nlm.nih.gov/pubmed/22866264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00085 |
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