Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor–activated macrophages

Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor–activated macrophages. Here we show that Cot/tpl2 regulates RSK, S6 ribosomal protein, and 4E-BP phosphorylation after stimulation of bone marrow–derived macrophages with lipopolysaccharide (LPS), poly I:C, or zymosan. The...

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Main Authors: López-Pelaéz, Marta, Fumagalli, Stefano, Sanz, Carlos, Herrero, Clara, Guerra, Susana, Fernandez, Margarita, Alemany, Susana
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2012
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408424/
https://ncbi.nlm.nih.gov/pubmed/22675026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-02-0135
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