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Pseudomonas aeruginosa Exotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability

Exotoxin Y (ExoY) is a type III secretion system effector found in ∼ 90% of the Pseudomonas aeruginosa isolates. Although it is known that ExoY causes inter-endothelial gaps and vascular leak, the mechanisms by which this occurs are poorly understood. Using both a bacteria-delivered and a codon-opti...

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Autors principals: Ochoa, Cristhiaan D., Alexeyev, Mikhail, Pastukh, Viktoriya, Balczon, Ron, Stevens, Troy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408204/
https://ncbi.nlm.nih.gov/pubmed/22637478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301440
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