Function of Human α3β4α5 Nicotinic Acetylcholine Receptors Is Reduced by the α5(D398N) Variant

Genome-wide studies have strongly associated a non-synonymous polymorphism (rs16969968) that changes the 398th amino acid in the nAChR α5 subunit from aspartic acid to asparagine (D398N), with greater risk for increased nicotine consumption. We have used a pentameric concatemer approach to express d...

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Hlavní autoři: George, Andrew A., Lucero, Linda M., Damaj, M. Imad, Lukas, Ronald J., Chen, Xiangning, Whiteaker, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408138/
https://ncbi.nlm.nih.gov/pubmed/22665477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.379339
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