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Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice()
Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutations in the collagen type I genes, resulting in bone fragility. Because the basis of the disease is molecular w...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3407875/ https://ncbi.nlm.nih.gov/pubmed/22449447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.03.007 |
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