Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model

The collagen molecule, which is the building block of collagen fibrils, is a triple helix of two α1(I) chains and one α2(I) chain. However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the substitution of the α2(I) chain by one α1(I) chain. As th...

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Bibliographic Details
Published in:J R Soc Interface
Main Authors: Andriotis, O. G., Chang, S. W., Vanleene, M., Howarth, P. H., Davies, D. E., Shefelbine, S. J., Buehler, M. J., Thurner, P. J.
Format: Artigo
Language:Inglês
Published: The Royal Society 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614505/
https://ncbi.nlm.nih.gov/pubmed/26468064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2015.0701
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