Spatial and Temporal Requirements for huntingtin (Htt) in Neuronal Migration and Survival during Brain Development

Huntington's disease (HD), caused by an expanded triplet repeat in the huntingtin (Htt) gene, results in extensive neuropathology, but study of the Htt gene in CNS development through gene knockout is problematic as the knockout leads to embryonic lethality in mice. Here, we report that the kno...

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Bibliografiska uppgifter
Huvudupphovsmän: Tong, Yiai, Ha, Thomas J., Liu, Li, Nishimoto, Andrew, Reiner, Anton, Goldowitz, Dan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2011
Ämnen:
Brief Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407803/
https://ncbi.nlm.nih.gov/pubmed/21994396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2774-11.2011
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