Spatial and Temporal Requirements for huntingtin (Htt) in Neuronal Migration and Survival during Brain Development

Huntington's disease (HD), caused by an expanded triplet repeat in the huntingtin (Htt) gene, results in extensive neuropathology, but study of the Htt gene in CNS development through gene knockout is problematic as the knockout leads to embryonic lethality in mice. Here, we report that the kno...

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Bibliographic Details
Main Authors: Tong, Yiai, Ha, Thomas J., Liu, Li, Nishimoto, Andrew, Reiner, Anton, Goldowitz, Dan
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407803/
https://ncbi.nlm.nih.gov/pubmed/21994396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2774-11.2011
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