Propylthiouracil Increases Sodium/Iodide Symporter Gene Expression and Iodide Uptake in Rat Thyroid Cells in the Absence of TSH

BACKGROUND: Propylthiouracil (PTU) and methimazole (MMI) are drugs that are widely used to treat Graves' disease. Although both exert an antithyroid effect primarily by blocking thyroid peroxidase activity, their molecular structure and other actions are different. We hypothesized that PTU and...

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Autori principali: Sue, Mariko, Akama, Takeshi, Kawashima, Akira, Nakamura, Hannah, Hara, Takeshi, Tanigawa, Kazunari, Wu, Huhehasi, Yoshihara, Aya, Ishido, Yuko, Hiroi, Naoki, Yoshino, Gen, Kohn, Leonard D., Ishii, Norihisa, Suzuki, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2012
Soggetti:
Thyroid Economy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407387/
https://ncbi.nlm.nih.gov/pubmed/22853729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2011.0290
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