Propylthiouracil Increases Sodium/Iodide Symporter Gene Expression and Iodide Uptake in Rat Thyroid Cells in the Absence of TSH

BACKGROUND: Propylthiouracil (PTU) and methimazole (MMI) are drugs that are widely used to treat Graves' disease. Although both exert an antithyroid effect primarily by blocking thyroid peroxidase activity, their molecular structure and other actions are different. We hypothesized that PTU and...

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Detalhes bibliográficos
Main Authors: Sue, Mariko, Akama, Takeshi, Kawashima, Akira, Nakamura, Hannah, Hara, Takeshi, Tanigawa, Kazunari, Wu, Huhehasi, Yoshihara, Aya, Ishido, Yuko, Hiroi, Naoki, Yoshino, Gen, Kohn, Leonard D., Ishii, Norihisa, Suzuki, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Thyroid Economy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407387/
https://ncbi.nlm.nih.gov/pubmed/22853729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2011.0290
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