Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

In Huntington's disease (HD; MIM ID #143100), a fatal neurodegenerative disorder, transcriptional dysregulation is a key pathogenic feature. Histone modifications are altered in multiple cellular and animal models of HD suggesting a potential mechanism for the observed changes in transcriptiona...

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Autores principales: McFarland, Karen N., Das, Sudeshna, Sun, Ting Ting, Leyfer, Dmitri, Xia, Eva, Sangrey, Gavin R., Kuhn, Alexandre, Luthi-Carter, Ruth, Clark, Timothy W., Sadri-Vakili, Ghazaleh, Cha, Jang-Ho J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407195/
https://ncbi.nlm.nih.gov/pubmed/22848491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041423
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