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Molecular mechanism of proton transport in CLC Cl(-)/H(+) exchange transporters

CLC proteins underlie muscle, kidney, bone, and other organ system function by catalyzing the transport of Cl(-) ions across cell and organellar membranes. Some CLC proteins are ion channels while others are pumps that exchange Cl(-) for H(+). The pathway through which Cl(-) ions cross the membrane...

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Autori principali: Feng, Liang, Campbell, Ernest B., MacKinnon, Roderick
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406864/
https://ncbi.nlm.nih.gov/pubmed/22753511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205764109
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