Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic β-Cells

The p21-activated kinase-1 (PAK1) is implicated in regulation of insulin exocytosis as an effector of Rho GTPases. PAK1 is activated by the onset of glucose-stimulated insulin secretion (GSIS) through phosphorylation of Thr-423, a major activation site by Cdc42 and Rac1. However, the kinase(s) that...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Nie, Jia, Sun, Chao, Faruque, Omar, Ye, Guangming, Li, Jia, Liang, Qiangrong, Chang, Zhijie, Yang, Wannian, Han, Xiao, Shi, Yuguang
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2012
Θέματα:
Signal Transduction
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406726/
https://ncbi.nlm.nih.gov/pubmed/22669945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.378372
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια