Tumor Necrosis Factor Receptor-associated Factor Family Protein 2 Is a Key Mediator of the Epidermal Growth Factor-induced Ribosomal S6 Kinase 2/cAMP-responsive Element-binding Protein/Fos Protein Signaling Pathway

TRAF2 has an important function in mediating the TNF-R signaling pathway toward activation of NF-κB and JNKs. Here we reveal a novel function of TRAF2 in the epidermal growth factor (EGF) signaling pathway. Knockdown of TRAF2 blocked EGF-induced AP-1 activity and anchorage- independent cell transfor...

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Bibliografische gegevens
Hoofdauteurs: Peng, Cong, Zhu, Feng, Wen, Weihong, Yao, Ke, Li, Shengqing, Zykova, Tatyana, Liu, Kangdong, Li, Xiang, Ma, Wei-Ya, Bode, Ann M., Dong, Zigang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406673/
https://ncbi.nlm.nih.gov/pubmed/22685297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359521
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