CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

Immunosuppressive tumor microenvironments can restrain antitumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA). Because CD40 activation can reverse immune suppression and drive antitumor T cell responses, we tested the combination of an agonist CD40 antibody with gemcitabine chemo...

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Hlavní autoři: Beatty, Gregory L., Chiorean, Elena G., Fishman, Matthew P., Saboury, Babak, Teitelbaum, Ursina R., Sun, Weijing, Huhn, Richard D., Song, Wenru, Li, Dongguang, Sharp, Leslie L., Torigian, Drew A., O’Dwyer, Peter J., Vonderheide, Robert H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406187/
https://ncbi.nlm.nih.gov/pubmed/21436454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198443
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