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Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors

BACKGROUND: Single-dose infusion of the agonistic anti-CD40 monoclonal antibody (mAb) CP-870,893 accomplishes immune activation and clinical responses in patients with advanced cancers, but repeat dosing of this agent has not been reported. RESULTS: Twenty-seven patients were enrolled. The most comm...

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Detalhes bibliográficos
Main Authors: Rüter, Jens, Antonia, Scott J, Burris, Howard A, Huhn, Richard D, Vonderheide, Robert H
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047092/
https://ncbi.nlm.nih.gov/pubmed/20855968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.10.13251
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