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Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2

BACKGROUND: In diabetic patients, the pharmacokinetics of injected human insulin does not permit optimal control of glycemia. Fast and slow acting insulin analogues have been developed, but they may have adverse properties, such as increased mitogenic or anti-apoptotic signaling. Insulin/IGF1 hybrid...

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Bibliografiske detaljer
Main Authors: Pierre-Eugene, Cécile, Pagesy, Patrick, Nguyen, Tuyet Thu, Neuillé, Marion, Tschank, Georg, Tennagels, Norbert, Hampe, Cornelia, Issad, Tarik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406060/
https://ncbi.nlm.nih.gov/pubmed/22848683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041992
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