Metabolic effect and receptor signalling profile of a non-metabolisable insulin glargine analogue

CONTEXT: Insulin glargine (GLA) is rapidly metabolized in vivo to metabolite M1, which has in vitro metabolic and mitogenic profiles comparable with human insulin (HI). OBJECTIVE: To investigate the pharmacologic and signalling profiles of a non-metabolizable analogue (A21Gly,DiD-Arg) insulin (D-GLA...

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Bibliographic Details
Published in:Arch Physiol Biochem
Main Authors: Werner, Ulrich, Korn, Marcus, Schmidt, Ronald, Wendrich, Thomas M., Tennagels, Norbert
Format: Artigo
Language:Inglês
Published: Informa UK Ltd. 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219851/
https://ncbi.nlm.nih.gov/pubmed/25144413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13813455.2014.950589
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