Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling

We investigated 1) the ability of purified glargine (GLA), metabolites 1 (M1) and 2 (M2), IGF-I, and NPH insulin to activate the insulin receptor (IR)-A and IR-B and IGF-I receptor (IGF-IR) in vitro; 2) plasma concentrations of GLA, M1, and M2 during long-term insulin therapy in type 2 diabetic pati...

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Main Authors: Varewijck, Aimee J., Yki-Järvinen, Hannele, Schmidt, Ronald, Tennagels, Norbert, Janssen, Joseph A.M.J.L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712030/
https://ncbi.nlm.nih.gov/pubmed/23569175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1773
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