Intact p53-Dependent Responses in miR-34–Deficient Mice

MicroRNAs belonging to the miR-34 family have been proposed as critical modulators of the p53 pathway and potential tumor suppressors in human cancers. To formally test these hypotheses, we have generated mice carrying targeted deletion of all three members of this microRNA family. We show that comp...

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Hlavní autoři: Concepcion, Carla P., Han, Yoon-Chi, Mu, Ping, Bonetti, Ciro, Yao, Evelyn, D'Andrea, Aleco, Vidigal, Joana A., Maughan, William P., Ogrodowski, Paul, Ventura, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406012/
https://ncbi.nlm.nih.gov/pubmed/22844244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002797
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