An allelic series of miR-17~92 mutant mice uncovers functional specialization and cooperation among members of a miRNA polycistron

Polycistronic microRNA clusters are a common feature of vertebrate genomes. The coordinated expression of miRNAs belonging to different seed families from a single transcription unit suggests functional cooperation, but this hypothesis has not been experimentally tested. Here we report the character...

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Bibliografske podrobnosti
izdano v:Nat Genet
Main Authors: Han, Yoon-Chi, Vidigal, Joana A., Mu, Ping, Yao, Evelyn, Singh, Irtisha, González, Alvaro J., Concepcion, Carla P., Bonetti, Ciro, Ogrodowski, Paul, Carver, Brett, Selleri, Licia, Betel, Doron, Leslie, Christina, Ventura, Andrea
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485521/
https://ncbi.nlm.nih.gov/pubmed/26029871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3321
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