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The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease
As neurons age, their survival depends on eliminating a growing burden of damaged, potentially toxic proteins and organelles—a capability that declines owing to aging and disease factors. Here, we review the two proteolytic systems principally responsible for protein quality control in neurons and t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405832/ https://ncbi.nlm.nih.gov/pubmed/22908190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006361 |
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