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Targeted Mutagenesis as a Rational Approach to Dengue Virus Vaccine Development

The recombinant dengue virus type 4 (rDEN4) vaccine candidate, rDEN4Δ30, was found to be highly infectious, immunogenic and safe in human volunteers. At the highest dose (10(5) PFU) evaluated in volunteers, 25% of the vaccinees had mild elevations in liver enzymes that were rarely seen at lower dose...

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Detalhes bibliográficos
Main Authors: Blaney, Joseph E., Durbin, Anna P., Murphy, Brian R., Whitehead, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405492/
https://ncbi.nlm.nih.gov/pubmed/19802584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-02215-9_11
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