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Targeted Mutagenesis as a Rational Approach to Dengue Virus Vaccine Development
The recombinant dengue virus type 4 (rDEN4) vaccine candidate, rDEN4Δ30, was found to be highly infectious, immunogenic and safe in human volunteers. At the highest dose (10(5) PFU) evaluated in volunteers, 25% of the vaccinees had mild elevations in liver enzymes that were rarely seen at lower dose...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405492/ https://ncbi.nlm.nih.gov/pubmed/19802584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-02215-9_11 |
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