Chemical Mutagenesis of Dengue Virus Type 4 Yields Mutant Viruses Which Are Temperature Sensitive in Vero Cells or Human Liver Cells and Attenuated in Mice

A recombinant live attenuated dengue virus type 4 (DEN4) vaccine candidate, 2AΔ30, was found previously to be generally well tolerated in humans, but a rash and an elevation of liver enzymes in the serum occurred in some vaccinees. 2AΔ30, a non-temperature-sensitive (non-ts) virus, contains a 30-nuc...

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Detalhes bibliográficos
Main Authors: Blaney, Joseph E., Johnson, Daniel H., Firestone, Cai-Yen, Hanson, Christopher T., Murphy, Brian R., Whitehead, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114545/
https://ncbi.nlm.nih.gov/pubmed/11559806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.20.9731-9740.2001
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