Aquaporin 4-Specific T Cells in Neuromyelitis Optica Exhibit a Th17 Bias and Recognize Clostridium ABC Transporter

OBJECTIVE: Aquaporin 4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell-dependent Ig subclass, indicating that AQP4-specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize AQP4-specific T cells in NMO patients and he...

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Main Authors: Varrin-Doyer, Michel, Spencer, Collin M, Schulze-Topphoff, Ulf, Nelson, Patricia A, Stroud, Robert M, C Cree, Bruce A, Zamvil, Scott S
Formato: Artigo
Idioma:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
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Rapid Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405197/
https://ncbi.nlm.nih.gov/pubmed/22807325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23651
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