Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity

AIM: To evaluate the safety of compacted DNA nanoparticles (NPs) in retinal pigment epithelial (RPE) cells. MATERIALS & METHODS: Enhanced GFP expression cassettes controlled by the RPE-specific vitelloform macular dystrophy promoter were constructed with and without a bacterial backbone and comp...

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Detaylı Bibliyografya
Asıl Yazarlar: Han, Zongchao, Koirala, Adarsha, Makkia, Rasha, Cooper, Mark J, Naash, Muna I
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404893/
https://ncbi.nlm.nih.gov/pubmed/22356602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.11.158
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