LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

In the mitotic exit network of budding yeast, Dbf2 kinase phosphorylates and regulates Cdc14 phosphatase. In contrast, no phosphatase substrates of LATS1/WARTS kinase, the mammalian equivalent of Dbf2, has been reported. To address this discrepancy, we performed phosphoproteomic screening using LATS...

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Main Authors: Chiyoda, Tatsuyuki, Sugiyama, Naoyuki, Shimizu, Takatsune, Naoe, Hideaki, Kobayashi, Yusuke, Ishizawa, Jo, Arima, Yoshimi, Tsuda, Hiroshi, Ito, Masaaki, Kaibuchi, Kozo, Aoki, Daisuke, Ishihama, Yasushi, Saya, Hideyuki, Kuninaka, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404884/
https://ncbi.nlm.nih.gov/pubmed/22641346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110110
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