LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

In the mitotic exit network of budding yeast, Dbf2 kinase phosphorylates and regulates Cdc14 phosphatase. In contrast, no phosphatase substrates of LATS1/WARTS kinase, the mammalian equivalent of Dbf2, has been reported. To address this discrepancy, we performed phosphoproteomic screening using LATS...

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Detalhes bibliográficos
Main Authors: Chiyoda, Tatsuyuki, Sugiyama, Naoyuki, Shimizu, Takatsune, Naoe, Hideaki, Kobayashi, Yusuke, Ishizawa, Jo, Arima, Yoshimi, Tsuda, Hiroshi, Ito, Masaaki, Kaibuchi, Kozo, Aoki, Daisuke, Ishihama, Yasushi, Saya, Hideyuki, Kuninaka, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404884/
https://ncbi.nlm.nih.gov/pubmed/22641346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110110
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