Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-κB Activation

Helicobacter pylori VacA induces multiple effects on susceptible cells, including vacuolation, mitochondrial damage, inhibition of cell growth, and enhanced cyclooxygenase-2 expression. To assess the ability of H. pylori to modulate the production of inflammatory mediators, we examined the mechanism...

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Detalhes bibliográficos
Main Authors: Hisatsune, Junzo, Nakayama, Masaaki, Isomoto, Hajime, Kurazono, Hisao, Mukaida, Naofumi, Mukhopadhyay, Asish K., Azuma, Takeshi, Yamaoka, Yoshio, Sap, Jan, Yamasaki, Eiki, Yahiro, Kinnosuke, Moss, Joel, Hirayama, Toshiya
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404739/
https://ncbi.nlm.nih.gov/pubmed/18354227
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