Helicobacter pylori VacA-induced Inhibition of GSK3 through the PI3K/Akt Signaling Pathway

Helicobacter pylori VacA toxin contributes to the pathogenesis and severity of gastric injury. We found that incubation of AZ-521 cells with VacA resulted in phosphorylation of protein kinase B (Akt) and glycogen synthase kinase-3β (GSK3β) through a PI3K-dependent pathway. Following phosphorylation...

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Detalhes bibliográficos
Main Authors: Nakayama, Masaaki, Hisatsune, Junzo, Yamasaki, Eiki, Isomoto, Hajime, Kurazono, Hisao, Hatakeyama, Masanori, Azuma, Takeshi, Yamaoka, Yoshio, Yahiro, Kinnosuke, Moss, Joel, Hirayama, Toshiya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615499/
https://ncbi.nlm.nih.gov/pubmed/18996844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806981200
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