Helicobacter pylori VacA Enhances Prostaglandin E(2) Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells

Treatment of AZ-521 cells with Helicobacter pylori VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, blocked elevation of COX-2 mRNA levels, whereas PD98059, which blocks the Erk1/2 cascade, partially...

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Hlavní autoři: Hisatsune, Junzo, Yamasaki, Eiki, Nakayama, Masaaki, Shirasaka, Daisuke, Kurazono, Hisao, Katagata, Yohtaro, Inoue, Hiroyasu, Han, Jiahuai, Sap, Jan, Yahiro, Kinnosuke, Moss, Joel, Hirayama, Toshiya
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951161/
https://ncbi.nlm.nih.gov/pubmed/17591797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00500-07
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