Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via PD-L1

Antagonism of CXCR4 disrupts the interaction between the CXCR4 receptor on HSCs and the CXCL12 expressed by stromal cells in the bone marrow, which subsequently results in the shedding of hematopoietic stem cells (HSCs) to the periphery. Due to their profound immunomodulatory effects, HSCs have emer...

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Autori principali: Fiorina, Paolo, Jurewicz, Mollie, Vergani, Andrea, Petrelli, Alessandra, Carvello, Michele, D’Addio, Francesca, Godwin, Jonathan G., Law, Kenneth, Wu, Erxi, Tian, Ze, Thoma, Gebhard, Kovarik, Jiri, La Rosa, Stefano, Capella, Carlo, Rodig, Scott, Zerwes, Hans-Guenter, Sayegh, Mohamed H., Abdi, Reza
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404615/
https://ncbi.nlm.nih.gov/pubmed/21131428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000799
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