Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via PD-L1

Antagonism of CXCR4 disrupts the interaction between the CXCR4 receptor on HSCs and the CXCL12 expressed by stromal cells in the bone marrow, which subsequently results in the shedding of hematopoietic stem cells (HSCs) to the periphery. Due to their profound immunomodulatory effects, HSCs have emer...

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Detalhes bibliográficos
Main Authors: Fiorina, Paolo, Jurewicz, Mollie, Vergani, Andrea, Petrelli, Alessandra, Carvello, Michele, D’Addio, Francesca, Godwin, Jonathan G., Law, Kenneth, Wu, Erxi, Tian, Ze, Thoma, Gebhard, Kovarik, Jiri, La Rosa, Stefano, Capella, Carlo, Rodig, Scott, Zerwes, Hans-Guenter, Sayegh, Mohamed H., Abdi, Reza
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404615/
https://ncbi.nlm.nih.gov/pubmed/21131428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000799
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