A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice

OBJECTIVE: To investigate a new clinically relevant immunoregulatory strategy based on treatment with murine Thymoglobulin mATG Genzyme and CTLA4-Ig in NOD mice to prevent allo- and autoimmune activation using a stringent model of islet transplantation and diabetes reversal. RESEARCH DESIGN AND METH...

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Main Authors: Vergani, Andrea, D'Addio, Francesca, Jurewicz, Mollie, Petrelli, Alessandra, Watanabe, Toshihiko, Liu, Kaifeng, Law, Kenneth, Schuetz, Christian, Carvello, Michele, Orsenigo, Elena, Deng, Shaoping, Rodig, Scott J., Ansari, Javeed M., Staudacher, Carlo, Abdi, Reza, Williams, John, Markmann, James, Atkinson, Mark, Sayegh, Mohamed H., Fiorina, Paolo
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2010
Teme:
Immunology and Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927948/
https://ncbi.nlm.nih.gov/pubmed/20805386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1264
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