Increased endogenous H(2)S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia

Hydrogen sulfide (H(2)S) has recently been identified as a regulator of various physiological events, including vasodilation, angiogenesis, antiapoptotic, and cellular signaling. Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine β-synthase (CBS), cystathionine γ-...

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Main Authors: Sen, Utpal, Sathnur, Pushpakumar B., Kundu, Sourav, Givvimani, Srikanth, Coley, Denise M., Mishra, Paras K., Qipshidze, Natia, Tyagi, Neetu, Metreveli, Naira, Tyagi, Suresh C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404527/
https://ncbi.nlm.nih.gov/pubmed/22517358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00398.2011
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