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Copper-Catalyzed Azide–Alkyne Click Chemistry for Bioconjugation

The copper-catalyzed azide-alkyne cycloaddition reaction is widely used for the connection of molecular entities of all sizes. A protocol is provided here for the process with biomolecules. Ascorbate is used as reducing agent to maintain the required cuprous oxidation state. Since these convenient c...

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Autori principali: Presolski, Stanislav I., Hong, Vu Phong, Finn, M.G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404492/
https://ncbi.nlm.nih.gov/pubmed/22844652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch110148
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