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Temporal Separation of Aggregation and Ubiquitination during Early Inclusion Formation in Transgenic Mice Carrying the Huntington’s Disease Mutation

Abnormal insoluble ubiqitinated protein aggregates are found in the brains of Huntington’s disease (HD) patients and in mice transgenic for the HTT mutation. Here, we describe the earliest stages of visible NII formation in brains of R6/2 mice killed between 2 and 6 weeks of age. We found that hunti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Gong, Belvin, Kielar, Catherine, Morton, A. Jennifer
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404089/
https://ncbi.nlm.nih.gov/pubmed/22848498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041450
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